Article
Bioinformatic analysis of gene sets regulated by ligand-activated and dominant-negative peroxisome proliferator-activated receptor gamma in mouse aorta.
Arteriosclerosis, thrombosis, and vascular biology - 1 Mar 2010
Keen Henry L, Halabi Carmen M, Beyer Andreas M, de Lange Willem J, Liu Xuebo, Maeda Nobuyo, Faraci Frank M, Casavant Thomas L, Sigmund Curt D
Abstract excerpt
OBJECTIVE: Drugs that activate peroxisome proliferator-activated receptor (PPAR) gamma improve glucose sensitivity and lower blood pressure, whereas dominant-negative mutations in PPARgamma cause severe insulin resistance and hypertension. We hypothesize that these PPARgamma mutants regulate targ...
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