Article
Association of a variation in the promoter region of the brain-derived neurotrophic factor gene with familial Parkinson's disease.
Parkinsonism & related disorders - 1 Jun 2004
Parsian Abbas, Sinha Rashmi, Racette Brad, Zhao Jing H, Perlmutter Joel S
Abstract excerpt
Genes coding for nerve growth factors involved in dopamine receptor and cellular regulation such as brain-derived neurotrophic factor (BDNF) are logical candidate genes for susceptibility to Parkinson's disease (PD). To determine the role of the BDNF gene in the development of familial and sporadic PD, we sequenced the promoter region of the gene using genomic DNA from patients with familial PD. Two single...
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