Article
BDNF genetic variants are associated with onset age of familial Parkinson disease: GenePD Study.
Neurology - 13 Dec 2005
Karamohamed S, Latourelle J C, Racette B A, Perlmutter J S, Wooten G F, Lew M, Klein C, Shill H, Golbe L I, Mark M H, Guttman M, Nicholson G, Wilk J B, Saint-Hilaire M, DeStefano A L, Prakash R, Tobin S, Williamson J, Suchowersky O, Labell N, Growdon B N J, Singer C, Watts R, Goldwurm S, Pezzoli G, Baker K B, Giroux M L, Pramstaller P P, Burn D J, Chinnery P, Sherman S, Vieregge P, Litvan I, Gusella J F, Myers R H, Parsian A
Abstract excerpt
Brain-derived neurotrophic factor (BDNF) stimulates neuronal growth and protects nigral dopamine neurons in animal models of Parkinson disease (PD). Therefore, BDNF is a candidate gene for PD. The authors investigated five single-nucleotide polymorphisms in 597 cases of familial PD. Homozygosity...
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