Article
Association of brain-derived neurotrophic factor (BDNF) Val66Met polymorphism with Parkinson's disease in a Greek population.
Journal of clinical neuroscience : official journal of the Neurosurgical Society of Australasia - 1 Dec 2011
Karakasis Charalambos, Kalinderi Kallirhoe, Katsarou Zoe, Fidani Liana, Bostantjopoulou Sevasti
Abstract excerpt
Brain-derived neurotrophic factor (BDNF) enhances survival of dopaminergic neurons in the substantia nigra, whereas in patients with Parkinson's disease (PD), the expression of BDNF mRNA is decreased, thus making BDNF a candidate gene for PD susceptibility. The association between BDNF Val66Met polymorphism and PD has been evaluated in several studies with controversial results. Thus, we determined the...
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