Article
Association studies of multiple candidate genes for Parkinson's disease using single nucleotide polymorphisms.
Annals of neurology - 1 Jan 2002
Momose Yoshio, Murata Miho, Kobayashi Kazuhiro, Tachikawa Masaji, Nakabayashi Yuko, Kanazawa Ichiro, Toda Tatsushi
Abstract excerpt
We studied 20 single nucleotide polymorphisms in 18 candidate genes for association with Parkinson's disease. We found that homozygosity for the V66M polymorphism of the brain-derived neurotrophic factor (BDNF) gene occurs more frequently in patients with Parkinson's disease than in unaffected controls (chi(2) = 5.46) and confirmed an association with the S18Y polymorphism of the UCH-L1 gene. Our results provide...
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