Article
Analysis of mutations and the association between polymorphisms in the cerebral dopamine neurotrophic factor (CDNF) gene and Parkinson disease.
Neuroscience letters - 15 Apr 2011
Choi Jung-Mi, Hong Jung-Hoon, Chae Min-Joo, Ngyuen Phuoc Hung, Kang Hyun-Sook, Ma Hyeo-Il, Kim Yun Joong
Abstract excerpt
Neurotrophic factors support the survival of dopaminergic neurons. The cerebral dopamine neurotrophic factor (CDNF) is a novel neurotrophic factor with strong trophic activity on dopaminergic neurons comparable to that of glial cell line-derived neurotrophic factor (GDNF). To investigate whether rare or common variants in CDNF are associated with Parkinson disease (PD), we performed mutation analysis of CDNF and...
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