Article
An application of conditional logistic regression and multifactor dimensionality reduction for detecting gene-gene interactions on risk of myocardial infarction: the importance of model validation.
BMC bioinformatics - 30 Apr 2004
Coffey Christopher S, Hebert Patricia R, Ritchie Marylyn D, Krumholz Harlan M, Gaziano J Michael, Ridker Paul M, Brown Nancy J, Vaughan Douglas E, Moore Jason H
Abstract excerpt
BACKGROUND: To examine interactions among the angiotensin converting enzyme (ACE) insertion/deletion, plasminogen activator inhibitor-1 (PAI-1) 4G/5G, and tissue plasminogen activator (t-PA) insertion/deletion gene polymorphisms on risk of myocardial infarction using data from 343 matched case-control pairs from the Physicians Health Study. We examined the data using both conditional logistic regression and the...
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