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Article

Multivariate generalized multifactor dimensionality reduction to detect gene-gene interactions.

BMC systems biology - 1 Jan 2013

Choi Jiin, Park Taesung

Abstract excerpt

BACKGROUND: Recently, one of the greatest challenges in genome-wide association studies is to detect gene-gene and/or gene-environment interactions for common complex human diseases. Ritchie et al. (2001) proposed multifactor dimensionality reduction (MDR) method for interaction analysis. MDR is a combinatorial approach to reduce multi-locus genotypes into high-risk and low-risk groups. Although MDR has been...

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PMID: 24565370
DOI: 10.1186/1752-0509-7-S6-S15
PMCID: PMC4029529

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DBP

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