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Article

Pair-wise multifactor dimensionality reduction method to detect gene-gene interactions in a case-control study.

Human heredity - 1 Jan 2010

He H, Oetting W S, Brott M J, Basu S

Abstract excerpt

OBJECTIVE: The identification of gene-gene interactions has been limited by small sample size and large number of potential interactions between genes. To address this issue, Ritchie et al. [2001] have proposed multifactor dimensionality reduction (MDR) method to detect polymorphisms associated with the disease risk. The MDR reduces the dimension of the genetic factors by classifying them into high-risk and...

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PMID: 19797910
DOI: 10.1159/000243155

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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