Article
Pair-wise multifactor dimensionality reduction method to detect gene-gene interactions in a case-control study.
Human heredity - 1 Jan 2010
He H, Oetting W S, Brott M J, Basu S
Abstract excerpt
OBJECTIVE: The identification of gene-gene interactions has been limited by small sample size and large number of potential interactions between genes. To address this issue, Ritchie et al. [2001] have proposed multifactor dimensionality reduction (MDR) method to detect polymorphisms associated w...
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