Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Diverse roles of K(ATP) channels learned from Kir6.2 genetically engineered mice.

Diabetes - 1 Mar 2000

Seino S, Iwanaga T, Nagashima K, Miki T

Abstract excerpt

The regulation of insulin secretion from pancreatic beta-cells depends critically on the activities of their plasma membrane ion channels. ATP-sensitive K+ channels (K(ATP) channels) are present in many cells and regulate a variety of cellular functions by coupling cell metabolism with membrane p...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Adenosine Triphosphate
Share to Genetic Engineering
Share to Infant

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Pancreas

Share to Pancreatic Diseases

Share to Potassium Channels

Share to Potassium Channels, Inwardly Rectifying

Source

Identifiers

PMID: 10868950
DOI: 10.2337/diabetes.49.3.311

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 1 Sept 2026. Prepared record publication-10868950-2026-09-01.1. Manifest publication-graph-cohort-2026-09-01.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 1 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Diverse roles of K(ATP) channels learned from Kir6.2 genetically engineered mice.PMID 10868950Read ↗

Physiological and pathophysiological roles of ATP-sensitive K+ channels.Semantic proximity Read ↗

Roles of ATP-sensitive K+ channels in cell survival and differentiation in the endocrine pancreas.Semantic proximity Read ↗

Of mice and men: K(ATP) channels and insulin secretion.Semantic proximity Read ↗

Expression of an activating mutation in the gene encoding the KATP channel subunit Kir6.2 in mouse pancreatic beta cells recapitulates neonatal diabetes.Semantic proximity Read ↗

ATP-sensitive K+ channel signaling in glucokinase-deficient diabetes.Semantic proximity Read ↗

The structure and function of the ATP-sensitive K+ channel in insulin-secreting pancreatic beta-cells.Semantic proximity Read ↗

Kir6.2 mutations causing neonatal diabetes provide new insights into Kir6.2-SUR1 interactions.Semantic proximity Read ↗

ATP-Sensitive Potassium Channels in Hyperinsulinism and Type 2 Diabetes: Inconvenient Paradox or New Paradigm?Semantic proximity Read ↗

Diabetes induced by gain-of-function mutations in the Kir6.1 subunit of the KATP channel.Semantic proximity Read ↗

Sur1 Knockout MiceSemantic proximity Read ↗

Functional analysis of six Kir6.2 (KCNJ11) mutations causing neonatal diabetes.Semantic proximity Read ↗

Molecular basis of Kir6.2 mutations associated with neonatal diabetes or neonatal diabetes plus neurological features.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.