Article
Of mice and men: K(ATP) channels and insulin secretion.
Recent progress in hormone research - 1 Jan 2001
Aguilar-Bryan L, Bryan J, Nakazaki M
Abstract excerpt
K(ATP) channels are a unique, small family of potassium (K+)-selective ion channels assembled from four inward rectifier pore-forming subunits, K(IR)6.x, paired with four sulfonylurea receptors (SURs), members of the adenosine triphosphate (ATP)-binding cassette superfamily. The activity of these channels can be regulated by metabolically driven changes in the ratio of adenosine diphosphate (ADP) to ATP,...
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