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Article

Steroidogenic factor 1 (SF1) is essential for pituitary gonadotrope function

15 Jan 2001

Abstract excerpt

Knockout mice lacking the orphan nuclear receptor steroidogenic factor 1 (SF1) exhibit a complex endocrine phenotype that includes adrenal and gonadal agenesis, impaired expression of pituitary gonadotropins, and absence of the ventromedial hypothalamic nucleus (VMH). These multiple defects complicate efforts to delineate primary versus secondary effects of SF1 deficiency in different tissues, such that its...

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PMID: 11124111
DOI: 10.1242/dev.128.2.147

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Steroidogenic factor 1 (SF1) is essential for pituitary gonadotrope functionPMID 11124111Read ↗

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