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Article

The nuclear receptor steroidogenic factor 1 is essential for the formation of the ventromedial hypothalamic nucleus.

1 Apr 1995

Abstract excerpt

The nuclear receptor steroidogenic factor 1 (SF-1) regulates the biosynthesis of the two essential mediators of male sexual differentiation, androgens and Müllerian-inhibiting substance, and is required for adrenal and gonadal development and gonadotropin expression. SF-1 is also expressed in the embryonic ventral diencephalon, subsequently localizing to the ventromedial hypothalamic nucleus, a region important...

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Share to Genetic and Clinical Aspects of Sex Determination and Chromosomal Abnormalities
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Source

Identifiers

PMID: 7659091
DOI: 10.1210/mend.9.4.7659091

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

Research trail→

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The nuclear receptor steroidogenic factor 1 is essential for the formation of the ventromedial hypothalamic nucleus.PMID 7659091Read ↗

Steroidogenic factor 1: an essential mediator of endocrine development.Semantic proximity Read ↗

Steroidogenic factor 1 (SF1) is essential for pituitary gonadotrope functionSemantic proximity Read ↗

Cell-Specific Knockout of Steroidogenic Factor 1 Reveals Its Essential Roles in Gonadal FunctionSemantic proximity Read ↗

Minireview: steroidogenic factor 1: its roles in differentiation, development, and disease.Semantic proximity Read ↗

Ventromedial hypothalamic nucleus-specific enhancer of Ad4BP/SF-1 gene.Semantic proximity Read ↗

Disruption of the gene encoding SF-1 alters the distribution of hypothalamic neuronal phenotypes.Semantic proximity Read ↗

Central Nervous System-Specific Knockout of Steroidogenic Factor 1 Results in Increased Anxiety-Like BehaviorSemantic proximity Read ↗

Steroidogenic Factor 1 Differentially Regulates Fetal and Adult Leydig Cell Development in Male Mice1Semantic proximity Read ↗

Knockout mice lacking steroidogenic factor 1 are a novel genetic model of hypothalamic obesity.Semantic proximity Read ↗

[SF-1, a key player in adrenal and gonadal differentiation: implications in gonadal dysgenesis and primary ovarian insufficiency].Semantic proximity Read ↗

Cloning and sequence analysis of the human gene encoding steroidogenic factor 1Semantic proximity Read ↗

The role of steroidogenic factor 1 (SF-1) in steroidogenic cell function of the testes and ovaries of mature miceSemantic proximity Read ↗

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