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Steroidogenic factor 1 (SF-1; Nr5a1 ) regulates the formation of the ovarian reserve

26 Jul 2023

Abstract excerpt

The ovarian follicle reserve, formed pre- or perinatally, comprises all oocytes for lifetime reproduction. Depletion of this reserve results in infertility. Steroidogenic factor 1 (SF-1; Nr5a1 ) and liver receptor homolog 1 (LRH-1; Nr5a2 ) are two orphan nuclear receptors that regulate adult endocrine function, but their role in follicle formation is unknown. We developed models of conditional depletion of SF-1...

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Share to Genetic and Clinical Aspects of Sex Determination and Chromosomal Abnormalities
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PMID: 37494420
DOI: 10.1073/pnas.2220849120

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