Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

New roads to FA/BRCA pathway: H2AX.

Cell cycle (Georgetown, Tex.) - 2 May 2007

Lyakhovich Alex, Surrallés Jordi

Abstract excerpt

We have recently described an involvement of H2AX into the Fanconi anemia (FA) BRCA pathway through recruitment of FA protein FANCD2 to the sites of stalled replication forks. We showed that BRCA1 mediates the recruitment of FANCD2 by gammaH2AX to damaged chromatin and cells deficient or depleted of H2AX exhibit an FA-like phenotype, including an excess of chromatid-type chromosomal aberrations and...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to BRCA2 Protein
Share to Chromatin
Share to DNA Repair

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Fanconi Anemia

Share to Fanconi Anemia Complementation Group D2 Protein

Share to Fanconi Anemia Complementation Group Proteins

Share to Histones

Share to Models, Biological

Source

Identifiers

PMID: 17471025
DOI: 10.4161/cc.6.9.4223

Genes

FANCD2
BRCA1
BRCA2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

New roads to FA/BRCA pathway: H2AX.PMID 17471025Read ↗

[Complex role of the FA proteins in providing genome stability].Semantic proximity Read ↗

Functional and physical interaction between the mismatch repair and FA-BRCA pathwaysSemantic proximity Read ↗

Expanded roles of the Fanconi anemia pathway in preserving genomic stability.Semantic proximity Read ↗

FANCI and FANCD2 have common as well as independent functions during the cellular replication stress response.Semantic proximity Read ↗

Fanconi anemia and DNA repair.Semantic proximity Read ↗

Fanconi anaemia and cancer: an intricate relationship.Semantic proximity Read ↗

Distinct roles of BRCA2 in replication fork protection in response to hydroxyurea and DNA interstrand crosslinksSemantic proximity Read ↗

The Fanconi anaemia genome stability and tumour suppressor network.Semantic proximity Read ↗

The Fanconi Anemia Pathway of Genomic MaintenanceSemantic proximity Read ↗

Cellular and molecular consequences of defective Fanconi anemia proteins in replication-coupled DNA repair: mechanistic insights.Semantic proximity Read ↗

Compromised repair of radiation-induced DNA double-strand breaks in Fanconi anemia fibroblasts in G2.Semantic proximity Read ↗

Fanconi anemia: causes and consequences of genetic instability.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.