Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Gbetagamma signaling and Ca2+ mobilization co-operate synergistically in a Sos and Rac-dependent manner in the activation of JNK by Gq-coupled receptors.

Cellular signalling - 1 Jul 2004

Chan Anthony S L, Wong Yung H

Abstract excerpt

The mechanism by which G(q)-coupled receptors stimulate the c-Jun N-terminal kinase (JNK) activity has not been fully delineated. Here, we showed that stimulation of endogenous G(q)-coupled receptors in human hepatocarcinoma HepG2 cells resulted in an Src family kinase- and Ca(2+)-dependent JNK activation. Cos-7 cells transfected with HA-tagged JNK and various G(q)-coupled receptors also exhibited similar...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Bradykinin
Share to GTP-Binding Protein alpha Subunits, Gq-G11

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to GTP-Binding Protein beta Subunits

Share to GTP-Binding Protein gamma Subunits

Share to JNK Mitogen-Activated Protein Kinases

Share to MAP Kinase Kinase 4

Share to Mitogen-Activated Protein Kinase Kinases

Share to rac GTP-Binding Proteins

Source

Identifiers

PMID: 15115661
DOI: 10.1016/j.cellsig.2003.12.007

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Gbetagamma signaling and Ca2+ mobilization co-operate synergistically in a Sos and Rac-dependent manner in the activation of JNK by Gq-coupled receptors.PMID 15115661Read ↗

Activation of Ras-dependent signaling pathways by G(14) -coupled receptors requires the adaptor protein TPR1.Semantic proximity Read ↗

Potent activation of RhoA by Galpha q and Gq-coupled receptors.Semantic proximity Read ↗

Involvement of protein kinase C and Src family tyrosine kinase in Galphaq/11-induced activation of c-Jun N-terminal kinase and p38 mitogen-activated protein kinase.Semantic proximity Read ↗

Activation of Jun kinase/stress-activated protein kinase by GTPase-deficient mutants of G alpha 12 and G alpha 13.Semantic proximity Read ↗

Galpha13 mediates activation of the cytosolic phospholipase A2alpha through fine regulation of ERK phosphorylation.Semantic proximity Read ↗

Beta-arrestin 2: a receptor-regulated MAPK scaffold for the activation of JNK3.Semantic proximity Read ↗

Src tyrosine kinase is a novel direct effector of G proteins.Semantic proximity Read ↗

Alpha-thrombin-mediated phosphatidylinositol 3-kinase activation through release of Gbetagamma dimers from Galphaq and Galphai2.Semantic proximity Read ↗

Phospholipase C-independent activation of glycogen synthase kinase-3beta and C-terminal Src kinase by Galphaq.Semantic proximity Read ↗

RhoA- and RhoD-dependent regulatory switch of Galpha subunit signaling by PAR-1 receptors in cellular invasion.Semantic proximity Read ↗

Preactivation permits subsequent stimulation of phospholipase C by G(i)-coupled receptors.Semantic proximity Read ↗

Distinct sites on G protein beta gamma subunits regulate different effector functions.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.