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Article

RhoA- and RhoD-dependent regulatory switch of Galpha subunit signaling by PAR-1 receptors in cellular invasion.

FASEB journal : official publication of the Federation of American Societies for Experimental Biology - 1 Apr 2002

Nguyen Quang-Dé, Faivre Sandrine, Bruyneel Erik, Rivat Christine, Seto Minoru, Endo Takeshi, Mareel Marc, Emami Shahin, Gespach Christian

Abstract excerpt

Thrombin and proteinase-activated receptors (PAR) specifically regulate several functions that markedly enhance the transformation phenotype such as inflammation, cell proliferation, tumor growth, and metastasis. We recently reported that thrombin inhibits cellular invasion induced by src, hepatocyte growth factor (HGF), and leptin in kidney and colonic epithelial cells via predominant activation of the pertussis...

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Share to ADP Ribose Transferases
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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to GTP-Binding Protein alpha Subunits, G12-G13

Share to Oncogene Protein pp60(v-src)

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Share to Receptor, PAR-1

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Share to Virulence Factors, Bordetella

Source

Identifiers

PMID: 11919159
DOI: 10.1096/fj.01-0525com

Genes

HGF

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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RhoA- and RhoD-dependent regulatory switch of Galpha subunit signaling by PAR-1 receptors in cellular invasion.PMID 11919159Read ↗

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