Article
Mutations/polymorphisms in the 55 kDa subunit of DNA polymerase epsilon in human colorectal cancer.
Cancer genomics & proteomics - 1 Jan 2000
Zhou Qi, Talvinen Kati, Sundström Jari, Elzagheid Adem, Pospiech Helmut, Syväoja Juhani E, Collan Yrjö
Abstract excerpt
BACKGROUND: Defects of some DNA polymerases have shown associations with cancer, but data on DNA polymerase epsilon are limited. This study investigated mutations in the 55 kDa subunit gene of DNA polymerase epsilon in colorectal cancer. MATERIALS AND METHODS: DNA from 16 human colorectal cancer and 9 control samples was studied with polymerase chain reaction-single-strand comformation polymorphism analysis and...
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