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Article

Constant light-induced retinal damage and the RPE65-MET450 variant: assessment of the NZW/LacJ mouse.

Molecular vision - 27 May 2005

Danciger Michael, Yang Haidong, Handschumacher Lisa, LaVail Matthew M

Abstract excerpt

PURPOSE: In a previous constant light-induced retinal damage (CLD) quantitative genetics study between the albino C57BL/6J-c2J (B6al) and BALB/c mouse strains, we identified a very strong and highly significant quantitative trait locus (QTL) on distal Chr 3 that we associated with a variant of the Rpe65 gene. The B6al strain carries the MET450 variant of RPE65 and is resistant to CLD while the BALB/c strain...

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Identifiers

PMID: 15947737

Genes

RPE65

Provenance

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