Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

The Rpe65 Leu450Met variation increases retinal resistance against light-induced degeneration by slowing rhodopsin regeneration.

The Journal of neuroscience : the official journal of the Society for Neuroscience - 1 Jan 2001

Wenzel A, Reme C E, Williams T P, Hafezi F, Grimm C

Abstract excerpt

Excessive light can cause retinal degeneration and may be an environmental cofactor accelerating retinal dystrophies and age-related diseases. In rodent models, the light damage susceptibility (LDS) of the retina is determined genetically. In two mouse strains, with different degrees of LDS, a Leu450Met variation in the pigment epithelial protein RPE65 was shown recently to cosegregate with low LDS. Because light...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to cis-trans-Isomerases
Share to Dose-Response Relationship, Radiation

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Eye Proteins

Share to Photoreceptor Cells, Vertebrate

Share to Retina

Share to Retinal Degeneration

Share to Rhodopsin

Source

Open in PubMed Open full text

Identifiers

PMID: 11150319
PMCID: PMC6762429

Genes

RPE65

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

The Rpe65 Leu450Met variation increases retinal resistance against light-induced degeneration by slowing rhodopsin regeneration.PMID 11150319Read ↗

Rpe65 as a modifier gene for inherited retinal degeneration.Semantic proximity Read ↗

Protection of Rpe65-deficient mice identifies rhodopsin as a mediator of light-induced retinal degenerationSemantic proximity Read ↗

Effect of Leu/Met variation at residue 450 on isomerase activity and protein expression of RPE65 and its modulation by variation at other residues.Semantic proximity Read ↗

New retinal light damage QTL in mice with the light-sensitive RPE65 LEU variant.Semantic proximity Read ↗

Electroretinographic evidence for altered phototransduction gain and slowed recovery from photobleaches in albino mice with a MET450 variant in RPE65.Semantic proximity Read ↗

Environmental Light Has an Essential Effect on the Disease Expression in a Dominant RPE65 Mutation.Semantic proximity Read ↗

Constant light-induced retinal damage and the RPE65-MET450 variant: assessment of the NZW/LacJ mouse.Semantic proximity Read ↗

R91W mutation in Rpe65 leads to milder early-onset retinal dystrophy due to the generation of low levels of 11-cis-retinalSemantic proximity Read ↗

Insights into the pathogenesis of dominant retinitis pigmentosa associated with a D477G mutation in RPE65.Semantic proximity Read ↗

Lack of Melanopsin Is Associated with Extreme Weight Loss in Mice upon Dietary Challenge.Semantic proximity Read ↗

In vivo dynamics of retinal injury and repair in the rhodopsin mutant dog model of human retinitis pigmentosa.Semantic proximity Read ↗

An inducible Cre mouse for studying roles of the RPE in retinal physiology and diseaseSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.