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Article

Rpe65 as a modifier gene for inherited retinal degeneration.

The European journal of neuroscience - 1 Feb 2006

Samardzija M, Wenzel A, Naash M, Remé C E, Grimm C

Abstract excerpt

Light accelerates progression of retinal degeneration in many animal models of retinitis pigmentosa (RP). A sequence variant in the Rpe65 gene (Rpe65(450Leu) or Rpe65(450Met)) can act as a modulator of light-damage susceptibility in mice by influencing the kinetics of rhodopsin regeneration and thus by modulating the photon absorption. Depending on exposure duration and light intensity applied, white fluorescent...

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Identifiers

PMID: 16519667
DOI: 10.1111/j.1460-9568.2006.04639.x
PMCID: PMC2823586

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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