Article
Lack of an association of apolipoprotein E gene polymorphisms with familial age-related macular degeneration.
Archives of ophthalmology (Chicago, Ill. : 1960) - 1 May 2003
Schultz Dennis W, Klein Michael L, Humpert Andrea, Majewski Jacek, Schain Mitchell, Weleber Richard G, Ott Jurg, Acott Ted S
Abstract excerpt
BACKGROUND: Previously, the epsilon 4 allele of apolipoprotein E (APOE) was reported to have a significant association with a decreased risk of age-related macular degeneration (AMD). In addition, the epsilon 2 allele of APOE was reported to be possibly associated with an increased risk of AMD. OBJECTIVE: To determine if APOE polymorphisms, previously reported to be associated with AMD, affect its expression in...
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