Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Exercise and Myocyte Enhancer Factor 2 Regulation in Human Skeletal Muscle

1 May 2004

Abstract excerpt

Overexpression of GLUT4 in skeletal muscle enhances whole-body insulin action. Exercise increases GLUT4 gene and protein expression, and a binding site for the myocyte enhancer factor 2 (MEF-2) is required on the GLUT4 promoter for this response. However, the molecular mechanisms involved remain elusive. In various cell systems, MEF-2 regulation is a balance between transcriptional repression by histone...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Adipose Tissue and Metabolism
Share to Exercise and Physiological Responses
Share to Muscle Physiology and Disorders

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Source

Identifiers

PMID: 15111488
DOI: 10.2337/diabetes.53.5.1208

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 8 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Exercise and Myocyte Enhancer Factor 2 Regulation in Human Skeletal MusclePMID 15111488Read ↗

Regulation of the human GLUT4 gene promoter: Interaction between a transcriptional activator and myocyte enhancer factor 2ASemantic proximity Read ↗

Regulation of Skeletal Myogenesis by Association of the MEF2 Transcription Factor with Class II Histone DeacetylasesSemantic proximity Read ↗

The deacetylase HDAC4 controls myocyte enhancing factor-2-dependent structural gene expression in response to neural activity.Semantic proximity Read ↗

Regulation of HDAC9 gene expression by MEF2 establishes a negative-feedback loop in the transcriptional circuitry of muscle differentiation.Semantic proximity Read ↗

Nuclear respiratory factor 1 controls myocyte enhancer factor 2A transcription to provide a mechanism for coordinate expression of respiratory chain subunits.Semantic proximity Read ↗

Distinct endothelial gene responses to acute exercise in skeletal muscleSemantic proximity Read ↗

Histone deacetylase degradation and MEF2 activation promote the formation of slow-twitch myofibers.Semantic proximity Read ↗

Differential regulation of the muscle-specific GLUT4 enhancer in regenerating and adult skeletal muscle.Semantic proximity Read ↗

Functional interaction of regulatory factors with the <i>Pgc-1</i> α promoter in response to exercise by in vivo imagingSemantic proximity Read ↗

NFATc1 controls skeletal muscle fiber type and is a negative regulator of MyoD activity.Semantic proximity Read ↗

Myocyte Enhancer Factor 2 Mediates Calcium-dependent Transcription of the Interleukin-2 Gene in T LymphocytesSemantic proximity Read ↗

A Ca(2+)-calmodulin-eEF2K-eEF2 signalling cascade, but not AMPK, contributes to the suppression of skeletal muscle protein synthesis during contractions.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.