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Article

Distinct endothelial gene responses to acute exercise in skeletal muscle

11 Aug 2025

Abstract excerpt

This study profiles the endothelial-specific transcriptional response to acute exercise at cell-type resolution. Comparative analysis with skeletal muscle fibers revealed distinct gene expression and upstream regulators. Key findings include endothelial-specific expression of exerkines, metabolic genes, and nitric oxide signaling. These results uncover a molecular basis for endothelial adaptation to exercise and...

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Identifiers

PMID: 40789176
DOI: 10.1152/ajpendo.00250.2025

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