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Article

Histone deacetylase degradation and MEF2 activation promote the formation of slow-twitch myofibers.

The Journal of clinical investigation - 1 Sept 2007

Potthoff Matthew J, Wu Hai, Arnold Michael A, Shelton John M, Backs Johannes, McAnally John, Richardson James A, Bassel-Duby Rhonda, Olson Eric N

Abstract excerpt

Skeletal muscle is composed of heterogeneous myofibers with distinctive rates of contraction, metabolic properties, and susceptibility to fatigue. We show that class II histone deacetylase (HDAC) proteins, which function as transcriptional repressors of the myocyte enhancer factor 2 (MEF2) transc...

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Source

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Identifiers

PMID: 17786239
DOI: 10.1172/JCI31960
PMCID: PMC1957540

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026. Prepared record publication-17786239-2026-09-02.2. Manifest publication-graph-cohort-2026-09-02.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 2 Sept 2026.

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