Article
Differential regulation of the muscle-specific GLUT4 enhancer in regenerating and adult skeletal muscle.
The Journal of biological chemistry - 17 Oct 2003
Moreno Horacio, Serrano Antonio L, Santalucía Tomàs, Gumá Anna, Cantó Carles, Brand Nigel J, Palacin Manuel, Schiaffino Stefano, Zorzano Antonio
Abstract excerpt
We have reported a novel functional co-operation among MyoD, myocyte enhancer factor-2 (MEF2), and the thyroid hormone receptor in a muscle-specific enhancer of the rat GLUT4 gene in muscle cells. Here, we demonstrate that the muscle-specific enhancer of the GLUT4 gene operates in skeletal muscle and is muscle fiber-dependent and innervation-independent. Under normal conditions, both in soleus and in extensor...
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