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Article

A Ca(2+)-calmodulin-eEF2K-eEF2 signalling cascade, but not AMPK, contributes to the suppression of skeletal muscle protein synthesis during contractions.

The Journal of physiology - 1 Apr 2009

Rose Adam J, Alsted Thomas J, Jensen Thomas E, Kobberø J Bjarke, Maarbjerg Stine J, Jensen Jørgen, Richter Erik A

Abstract excerpt

Skeletal muscle protein synthesis rate decreases during contractions but the underlying regulatory mechanisms are poorly understood. It was hypothesized that there would be a coordinated regulation of eukaryotic elongation factor 2 (eEF2) and eukaryotic initiation factor 4E-binding protein 1 (4EBP1) phosphorylation by signalling cascades downstream of rises in intracellular [Ca(2+)] and decreased energy charge...

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Identifiers

PMID: 19188248
DOI: 10.1113/jphysiol.2008.167528
PMCID: PMC2678225

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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