Article
A Notch positive feedback in the intestinal stem cell niche is essential for stem cell self-renewal.
Molecular systems biology - 28 Apr 2017
Chen Kai-Yuan, Srinivasan Tara, Tung Kuei-Ling, Belmonte Julio M, Wang Lihua, Murthy Preetish Kadur Lakshminarasimha, Choi Jiahn, Rakhilin Nikolai, King Sarah, Varanko Anastasia Kristine, Witherspoon Mavee, Nishimura Nozomi, Glazier James A, Lipkin Steven M, Bu Pengcheng, Shen Xiling
Abstract excerpt
The intestinal epithelium is the fastest regenerative tissue in the body, fueled by fast-cycling stem cells. The number and identity of these dividing and migrating stem cells are maintained by a mosaic pattern at the base of the crypt. How the underlying regulatory scheme manages this dynamic stem cell niche is not entirely clear. We stimulated intestinal organoids with Notch ligands and inhibitors and...
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