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Article

HHIP's dynamic role in epithelial wound healing reveals a potential mechanism of COPD susceptibility.

Proceedings of the National Academy of Sciences of the United States of America - 2 Jun 2026

Deritei Dávid, Anamika Wardatul Jannat, Zhou Anny Xiaobo, Yun Jeong H, Sauler Maor, Cho Michael H, Silverman Edwin K, Ravasz Regan Erzsébet, Glass Kimberly

Abstract excerpt

Genetic variants near Hedgehog interacting protein (HHIP) have been consistently associated with increased risk for chronic obstructive pulmonary disease (COPD), the third leading cause of death worldwide. However, HHIP's role in COPD pathogenesis remains elusive. Canonically, HHIP is a negative regulator of the Hedgehog pathway and downstream GLI1 and GLI2 activation. The Hedgehog pathway plays an important role...

Read the complete abstract on PubMed

Topics

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Share to Epithelial Cells
Share to Epithelial-Mesenchymal Transition

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Hedgehog Proteins

Share to Membrane Glycoproteins

Share to Pulmonary Disease, Chronic Obstructive

Share to Wound Healing

Share to Zinc Finger Protein GLI1

Share to Zinc Finger Protein Gli2

Source

Open in PubMed Open full text

Identifiers

PMID: 42190016
DOI: 10.1073/pnas.2424377123
PMCID: PMC13225619

Genes

HHIP
GLI1
GLI2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026.

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