Article
Roles of the Nkx3.1 homeobox gene in prostate organogenesis and carcinogenesis.
Developmental dynamics : an official publication of the American Association of Anatomists - 1 Dec 2003
Shen Michael M, Abate-Shen Cory
Abstract excerpt
Although it is often presumed that the molecular pathways that underlie normal organogenesis are similar to those perturbed during carcinogenesis, few examples exist of tissue-specific regulatory genes that play central roles in both processes. In the case of the prostate gland, molecular genetic analyses have demonstrated that the Nkx3.1 homeobox gene plays an important role in normal differentiation of the...
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