Polymorphisms of CYP1A1 and GSTM1 influence the in vivo function of CYP1A2.

doi:10.1016/s0027-5107(97)00036-5

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Article

Polymorphisms of CYP1A1 and GSTM1 influence the in vivo function of CYP1A2.

Mutation research - 12 May 1997

MacLeod S, Sinha R, Kadlubar F F, Lang N P

Abstract excerpt

Differences in human cancer susceptibility have been attributed to polymorphisms of carcinogen metabolizing enzymes. Our efforts have focused on the systems responsible for metabolism of aromatic and heterocyclic amines found in cigarette smoke and in cooked foods. Cytochrome P4501A2 (CYP1A2), wh...

Topics

Arylamine N-Acetyltransferase
Biotransformation
Cooking
Cytochrome P-450 CYP1A1
Cytochrome P-450 CYP1A2
Gene Expression
Genotype
Glutathione Transferase
Humans
Meat
Polymorphism, Genetic
Smoke

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