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Article

Comparative genomics of the Hedgehog loci in chordates and the origins of Shh regulatory novelties.

Scientific reports - 1 Jan 2012

Irimia Manuel, Royo Jose L, Burguera Demian, Maeso Ignacio, Gómez-Skarmeta José L, Garcia-Fernandez Jordi

Abstract excerpt

The origin and evolution of the complex regulatory landscapes of some vertebrate developmental genes, often spanning hundreds of Kbp and including neighboring genes, remain poorly understood. The Sonic Hedgehog (Shh) genomic regulatory block (GRB) is one of the best functionally characterized examples, with several discrete enhancers reported within its introns, vast upstream gene-free region and neighboring...

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Identifiers

PMID: 22666536
DOI: 10.1038/srep00433
PMCID: PMC3364491

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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