Article
Single-molecule analysis for molecular haplotyping.
Human mutation - 1 May 2004
Kwok Pui-Yan, Xiao Ming
Abstract excerpt
In the genome era, there is great hope that genetic approaches such as linkage equilibrium mapping can be used to study common human disorders using a case-control population association study design. Ideally, the parental chromosomes are marked so that chromosomal regions in the form of haplotypes are compared in these studies to increase the power of association. Determining the haplotypes in a diploid...
Topics
- Alleles
- DNA Mutational Analysis
- Fluorescent Dyes
- Haplotypes
- Humans
- Polymerase Chain Reaction
- Polymorphism, Single Nucleotide