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Article

Direct determination of molecular haplotypes by chromosome microdissection.

Nature methods - 1 Apr 2010

Ma Li, Xiao Yan, Huang Hui, Wang Qingwei, Rao Weinian, Feng Yue, Zhang Kui, Song Qing

Abstract excerpt

Direct observation of haplotypes is still technically challenging. Here we report a method for the determination of haplotypes through chromosome microdissection. We determined human long-range chromosomal haplotypes with more than 98.85% accuracy at 24,245 genome-wide heterozygous single-nucleotide polymorphism (SNP) loci.

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Identifiers

PMID: 20305652
DOI: 10.1038/nmeth.1443
PMCID: PMC2871314

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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