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Article

Whole-genome molecular haplotyping of single cells.

Nature biotechnology - 1 Jan 2011

Fan H Christina, Wang Jianbin, Potanina Anastasia, Quake Stephen R

Abstract excerpt

Conventional experimental methods of studying the human genome are limited by the inability to independently study the combination of alleles, or haplotype, on each of the homologous copies of the chromosomes. We developed a microfluidic device capable of separating and amplifying homologous copies of each chromosome from a single human metaphase cell. Single-nucleotide polymorphism (SNP) array analysis of...

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PMID: 21170043
DOI: 10.1038/nbt.1739
PMCID: PMC4098715

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

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