Article
COMT158 polymorphism and hostility.
American journal of medical genetics. Part B, Neuropsychiatric genetics : the official publication of the International Society of Psychiatric Genetics - 15 May 2004
Volavka Jan, Kennedy James L, Ni Xingqun, Czobor Pal, Nolan Karen, Sheitman Brian, Lindenmayer Jean-Pierre, Citrome Leslie, McEvoy Joseph, Lieberman Jeffrey A
Abstract excerpt
The main study was designed primarily to compare the clinical effects of four antipsychotics in 157 patients with schizophrenia or schizoaffective disorder. The secondary genetic study, reported here, is based on a subset of 60 patients who consented to genotyping assays. Based on previous work with the catechol-O-methyltransferase (COMT) 158 polymorphism, we hypothesized that the Met-Met homozygotes would be...
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