Analysis of COMT Val158Met polymorphisms and methylation in Chinese male schizophrenia patients with homicidal behavior.

doi:10.1007/s00414-018-1773-0

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Article

Analysis of COMT Val158Met polymorphisms and methylation in Chinese male schizophrenia patients with homicidal behavior.

International journal of legal medicine - 1 Nov 2018

Hu Yikai, Li Chenghu, Wang Yangfan, Li Qinhan, Liu Yidong, Liao Shengde, Cao Peiqing, Xu Hongmei

Abstract excerpt

Schizophrenia is a severe mental disorder, and its mechanisms have not been fully elucidated. A functional single nucleotide polymorphism (SNP) present in the catechol-O-methyltransferase (COMT) gene, Val158Met (rs4680) (Chr22: 19,963,498), is possibly related to the violent behavior of schizophrenia patients. However, the specific variant that causes violent behavior is still unknown. Since the Val variation of...

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PMID: 29455339
DOI: 10.1007/s00414-018-1773-0

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COMT

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

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