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Mitochondrial DNA polymorphisms as risk factors for Parkinson's disease and Parkinson's disease dementia.

Human genetics - 1 Jun 2004

Autere Jaana, Moilanen Jukka S, Finnilä Saara, Soininen Hilkka, Mannermaa Arto, Hartikainen Päivi, Hallikainen Merja, Majamaa Kari

Abstract excerpt

The activity of complex I of the mitochondrial respiratory chain has been found to be decreased in patients with Parkinson's disease (PD), but no mutations have been identified in genes encoding complex I subunits. Recent studies have suggested that polymorphisms in mitochondrial DNA (mtDNA)-encoded complex I genes (MTND) modify susceptibility to PD. We hypothesize that the risk of PD is conveyed by the total...

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Identifiers

PMID: 15108120
DOI: 10.1007/s00439-004-1123-9

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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