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Mitochondrial DNA haplogroups in early-onset Alzheimer's disease and frontotemporal lobar degeneration

2 Feb 2010

Abstract excerpt

BACKGROUND: Mitochondrial dysfunction, oxidative damage and the accumulation of somatic mutations in mitochondrial DNA (mtDNA) have been associated with certain neurodegenerative disorders. Previous studies have also provided controversial results on the association of mtDNA haplogroups with susceptibility to Alzheimer's disease (AD), but possible relationships between mtDNA and frontotemporal lobar degeneration...

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PMID: 20181062
DOI: 10.1186/1750-1326-5-8

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