Article
Genetic variation in DLG5 is associated with inflammatory bowel disease.
Nature genetics - 1 May 2004
Stoll Monika, Corneliussen Brit, Costello Christine M, Waetzig Georg H, Mellgard Bjorn, Koch W Andreas, Rosenstiel Philip, Albrecht Mario, Croucher Peter J P, Seegert Dirk, Nikolaus Susanna, Hampe Jochen, Lengauer Thomas, Pierrou Stefan, Foelsch Ulrich R, Mathew Christopher G, Lagerstrom-Fermer Maria, Schreiber Stefan
Abstract excerpt
Crohn disease and ulcerative colitis are two subphenotypes of inflammatory bowel disease (IBD), a complex disorder resulting from gene-environment interaction. We refined our previously defined linkage region for IBD on chromosome 10q23 and used positional cloning to identify genetic variants in DLG5 associated with IBD. DLG5 encodes a scaffolding protein involved in the maintenance of epithelial integrity. We...
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