Article
The role of inflammatory bowel disease susceptibility loci in multiple sclerosis and systemic lupus erythematosus.
Genes and immunity - 1 Jun 2006
De Jager P L, Graham R, Farwell L, Sawcer S, Richardson A, Behrens T W, Compston A, Hafler D A, Kere J, Vyse T J, Rioux J D
Abstract excerpt
To date, three loci have been validated to confer susceptibility to inflammatory bowel disease (IBD): the CARD15/NOD2 gene, the discs large homolog 5 gene (DLG5), and the IBD5 locus on 5q31 (IBD5). We have explored the possibility that these loci may also be associated with susceptibility to two other chronic inflammatory diseases, multiple sclerosis (MS) and systemic lupus erythematosus (SLE). As the CARD15 risk...
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