Article
The Crohn's disease susceptibility gene DLG5 as a member of the CARD interaction network.
Journal of molecular medicine (Berlin, Germany) - 1 Apr 2008
Friedrichs Frauke, Henckaerts Liesbet, Vermeire Severine, Kucharzik Torsten, Seehafer Tanja, Möller-Krull Maren, Bornberg-Bauer Erich, Stoll Monika, Weiner January
Abstract excerpt
Discs large homolog 5 (DLG5), a member of the membrane-associated guanylate kinase (MAGUK) family of scaffolding proteins, has been associated with Crohn's disease (CD), but its role in the pathogenesis of this inflammatory bowel disease is disputed. Here, we used sequence comparisons and phylogenies to analyse the DLG5 gene and its protein product. We identified a 5' exon, which codes for an N-terminal caspase...
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