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Article

Sequence variation, linkage disequilibrium and association with Crohn's disease on chromosome 5q31.

Genes and immunity - 1 Jul 2006

Onnie C, Fisher S A, King K, Mirza M, Roberts R, Forbes A, Sanderson J, Lewis C M, Mathew C G

Abstract excerpt

Chromosome 5q31 contains a cluster of genes involved in immune response, including a 250 kb risk haplotype associated with Crohn's disease (CD) susceptibility. Recently, two functional variants in SLC22A4 and SLC22A5 (L503F and G-207C), encoding the cation transporters OCTN1 and OCTN2, were proposed as causal variants for CD, but with conflicting genetic evidence regarding their contribution. We investigated this...

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Source

Identifiers

PMID: 16724073
DOI: 10.1038/sj.gene.6364307

Genes

RAD50
SLC22A4
SLC22A5

Variants

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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