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Article

Hid, Rpr and Grim negatively regulate DIAP1 levels through distinct mechanisms.

Nature cell biology - 1 Jun 2002

Yoo Soon Ji, Huh Jun R, Muro Israel, Yu Hong, Wang Lijuan, Wang Susan L, Feldman R M Renny, Clem Rollie J, Müller H-Arno J, Hay Bruce A

Abstract excerpt

Inhibitor of apoptosis (IAP) proteins suppress apoptosis and inhibit caspases. Several IAPs also function as ubiquitin-protein ligases. Regulators of IAP auto-ubiquitination, and thus IAP levels, have yet to be identified. Here we show that Head involution defective (Hid), Reaper (Rpr) and Grim downregulate Drosophila melanogaster IAP1 (DIAP) protein levels. Hid stimulates DIAP1 polyubiquitination and...

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Identifiers

PMID: 12021767
DOI: 10.1038/ncb793

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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Hid, Rpr and Grim negatively regulate DIAP1 levels through distinct mechanisms.PMID 12021767Read ↗

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