Article
The Schizosaccharomyces pombe Pccs protein functions in both copper trafficking and metal detoxification pathways.
The Journal of biological chemistry - 2 Jul 2004
Laliberté Julie, Whitson Lisa J, Beaudoin Jude, Holloway Stephen P, Hart P John, Labbé Simon
Abstract excerpt
Because copper is both an essential cofactor and a toxic metal, different strategies have evolved to appropriately regulate its homeostasis as a function of changing environmental copper levels. In this report, we describe a metallochaperone-like protein from Schizosaccharomyces pombe that maintains the delicate balance between essentiality and toxicity. This protein, designated Pccs, has four distinct domains....
Topics
- Alleles
- Amino Acid Motifs
- Amino Acid Sequence
- Biological Transport
- Cadmium
- Copper
- Cysteine
- Dose-Response Relationship, Drug
- Green Fluorescent Proteins
- Humans
- Ions
- Luminescent Proteins
- Molecular Chaperones