Purine biosynthetic genes are required for cadmium tolerance in Schizosaccharomyces pombe.

doi:10.1128/mcb.12.12.5301-5310.1992

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Article

Purine biosynthetic genes are required for cadmium tolerance in Schizosaccharomyces pombe.

Molecular and cellular biology - 1 Dec 1992

Speiser D M, Ortiz D F, Kreppel L, Scheel G, McDonald G, Ow D W

Abstract excerpt

Phytochelatins (PCs) are metal-chelating peptides produced in plants and some fungi in response to heavy metal exposure. A Cd-sensitive mutant of the fission yeast Schizosaccharomyces pombe, defective in production of a PC-Cd-sulfide complex essential for metal tolerance, was found to harbor mutations in specific genes of the purine biosynthetic pathway. Genetic analysis of the link between metal complex...

Topics

Adenylosuccinate Synthase
Amino Acid Sequence
Base Sequence
Cadmium
DNA, Fungal
Drug Resistance, Microbial
Gene Deletion
Genes, Fungal
Genetic Engineering
Glutathione
Metalloproteins

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Molecular Sequence Data

Molecular Weight

Mutation

Phenotype

Phytochelatins

Plant Proteins

Purines

Source

Open in PubMed Open full text

Identifiers

PMID: 1448066
DOI: 10.1128/mcb.12.12.5301-5310.1992
PMCID: PMC360467

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 29 Aug 2026. Prepared record publication-1448066-2026-08-29.1. Manifest publication-graph-cohort-2026-08-29.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 29 Aug 2026.

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