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Article

A physiological role for Saccharomyces cerevisiae copper/zinc superoxide dismutase in copper buffering.

The Journal of biological chemistry - 15 Dec 1995

Culotta V C, Joh H D, Lin S J, Slekar K H, Strain J

Abstract excerpt

The copper toxicity of yeast lacking the CUP1 metallothionein is suppressed by overexpression of the CRS4 gene. We now demonstrate that CRS4 is equivalent to SOD1, encoding copper/zinc superoxide dismutase (SOD). While overexpression of SOD1 enhanced copper resistance, a deletion of SOD1, but not SOD2 (encoding manganese SOD), conferred an increased sensitivity toward copper. This role of SOD1 in copper buffering...

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Source

Identifiers

PMID: 8530401
DOI: 10.1074/jbc.270.50.29991

Genes

SOD1
SOD2

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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