Article
A physiological role for Saccharomyces cerevisiae copper/zinc superoxide dismutase in copper buffering.
The Journal of biological chemistry - 15 Dec 1995
Culotta V C, Joh H D, Lin S J, Slekar K H, Strain J
Abstract excerpt
The copper toxicity of yeast lacking the CUP1 metallothionein is suppressed by overexpression of the CRS4 gene. We now demonstrate that CRS4 is equivalent to SOD1, encoding copper/zinc superoxide dismutase (SOD). While overexpression of SOD1 enhanced copper resistance, a deletion of SOD1, but not...
Topics
- Copper
- Dose-Response Relationship, Drug
- Drug Resistance, Microbial
- Genes, Fungal
- Genotype
- Homeostasis
- Kinetics
- Metallothionein
- Mutation
- Saccharomyces cerevisiae
- Superoxide Dismutase