Sequence, mapping and disruption of CCC2, a gene that cross-complements the Ca(2+)-sensitive phenotype of csg1 mutants and encodes a P-type ATPase belonging to the Cu(2+)-ATPase subfamily.

Abstract excerpt

We have isolated, sequenced, mapped and disrupted a gene, CCC2, from Saccharomyces cerevisiae. This gene displays non-allelic complementation of the Ca(2+)-sensitive phenotype conferred by the csg1 mutation. Analysis of the CCC2p amino acid sequence reveals that it encodes a member of the P-type ATPase family and is most similar to a subfamily thought to consist of Cu2+ transporters, including the human genes...

Topics

• Adenosine Triphosphatases
• Amino Acid Sequence
• Base Sequence
• Calcium
• Cation Transport Proteins
• Cloning, Molecular
• Copper
• Copper Transport Proteins
• DNA, Fungal
• Fungal Proteins