Serum deprivation induces a unique hypercontractile phenotype of cultured smooth muscle cells.

doi:10.1152/ajpcell.1998.274.5.C1206

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Article

Serum deprivation induces a unique hypercontractile phenotype of cultured smooth muscle cells.

The American journal of physiology - 1 May 1998

Ma X, Wang Y, Stephens N L

Abstract excerpt

Chronic asthma is characterized by hypertrophy and hyperplasia of airway smooth muscle cells (SMC) that limit airflow by a geometric effect. Whether contractility of airway SMC is altered is not clear. Cultured cells were used as a model of hyperplasia. Phenotypic changes seen indicated conversio...

Topics

Actins
Animals
Cell Differentiation
Cells, Cultured
Culture Media, Serum-Free
Dogs
Muscle Contraction
Muscle, Smooth
Myosin Heavy Chains
Myosin-Light-Chain Kinase
Phenotype
Trachea

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