Article
Expression of the dystrophin-glycoprotein complex is a marker for human airway smooth muscle phenotype maturation.
American journal of physiology. Lung cellular and molecular physiology - 1 Jan 2008
Sharma Pawan, Tran Thai, Stelmack Gerald L, McNeill Karol, Gosens Reinoud, Mutawe Mark M, Unruh Helmut, Gerthoffer William T, Halayko Andrew J
Abstract excerpt
Airway smooth muscle (ASM) cells may contribute to asthma pathogenesis through their capacity to switch between a synthetic/proliferative and a contractile phenotype. The multimeric dystrophin-glycoprotein complex (DGC) spans the sarcolemma, linking the actin cytoskeleton and extracellular matrix. The DGC is expressed in smooth muscle tissue, but its functional role is not fully established. We tested whether...
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